Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Introduction

Number of entries
New entries 217
Updated entries 178,487
Unchanged entries 378,787
Total 557,491
Entries with updated sequences 16
With a fragmented AA sequence 9,149
With known alternative products 25,165
Protein Existence (PE) Number of entries
1 Evidence at protein level 98,487
2 Evidence at transcript level 57,196
3 Inferred from homology 386,308
4 Predicted 13,636
5 Uncertain 1,864

Taxonomic Origin

Swiss-Prot entries per taxonomic group


Statistics on the number of species

Number of species in
New entries 37
Updated entries 4,197
Unchanged entries 8,189
Total 9,421

Sequence data

The shortest sequence is P83570 at 2 AA while the longest sequence is A2ASS6 at 35,213 AA

Some annotation statistics

General Annotation (comments)

Annotations Entries
Allergenic properties 715 715
Alternative products 25,165 25,165
Biophysicochemical properties 7,977 7,977
Biotechnological use 894 883
Catalytic activity 265,747 235,226
Caution 34,565 25,736
Cofactor 214,703 0
Developmental stage 11,863 11,862
Involvement in disease 6,831 4,573
Disruption phenotype 13,470 13,470
Domain 47,801 41,250
Enzyme regulation 14,509 14,507
Function 463,090 442,912
Induction 20,271 20,259
Mass spectrometry 0 0
Miscellaneous 38,151 35,168
Pathway 137,630 124,830
Pharmaceutical use 112 110
Polymorphism 1,289 1,233
Post-translational modification 55,320 41,079
RNA Editing 627 627
Sequence caution 60,852 44,122
Sequence similarities 505,808 501,659
Subcellular Location uniprot:(reviewed:yes) 0
Subunit structure 276,227 275,876
Tissue specificity 45,112 45,111
Toxic dose 665 609

Sequence Annotation (features)

Annotations Entries
Molecule processing 658,622 557,491
Chain 565,344 550,524
Initiator methionine 17,250 17,203
Peptide 11,443 7,860
Propeptide 14,111 12,026
Signal peptide 41,431 41,429
Transit peptide 9,043 8,927
Regions 1,330,482 321,551
Calcium binding 4,168 1,727
Coiled-coil 21,971 15,180
Compositional bias 58,875 31,669
DNA binding 11,598 10,490
Domain 192,664 118,749
Motif 42,346 27,757
Nucleotide binding 156,450 85,013
Repeat 104,950 14,680
Region 195,422 92,763
Topological domain 139,629 28,678
Transmembrane 369,419 77,087
Zinc finger 30,356 13,312
Sites 998,699 206,874
Active site 163,025 98,902
Metal binding 376,272 93,544
Binding site 402,687 105,958
Other 56,715 31,447
Amino acid modifications 525,419 115,129
Cross-link 23,575 8,429
Disulfide bond 123,307 33,344
Glycosylation 115,584 29,611
Lipidation 12,997 8,388
Modified residue 249,598 71,500
Non-standard residue 358 283
Natural variations 148,156 31,236
Natural variant 148,156 31,236
Alternative sequence 51,837 21,936
Experimental info 239,148 65,768
Mutagenesis 66,509 14,761
Non-adjacent residues 2,257 787
Non-terminal residue 12,372 9,490
Sequence conflict 153,581 47,276
Sequence uncertainty 4,429 788
Secondary structure 565,316 23,814
Helix 247,503 22,952
Turn 59,577 18,604
Beta strand 258,236 21,612

Citation usage

Citation type Citations Entries
Submission173,648155,165
Journal article1,028,262453,196
Book1,7361,713
Thesis435432
Patent201196
Unpublished observations399395
Online journal article621607

Additional automatically mapped literature

Citation type Citations Entries
Journal articles 853,657 68,287

For information about which journals are used in citing or mapping to UniProtKB see the journals section.

Database Cross-Reference Statistics

DatabaseEntities linked toEntries
Sequence databases
CCDS033,941
EMBL0545,848
PIR0113,642
RefSeq0462,500
UniGene096,199
3D structure databases
DisProt0703
PDB026,351
PDBsum026,351
ProteinModelPortal0447,954
SMR0441,473
Protein-protein interaction databases
BioGrid050,096
CORUM05,168
DIP017,313
ELM01,809
IntAct051,282
MINT021,763
STRING0332,222
Chemistry
BindingDB05,011
ChEMBL06,527
DrugBank03,639
GuidetoPHARMACOLOGY02,028
SwissLipids01,249
Protein family/group databases
Allergome01,139
CAZy08,528
ESTHER02,491
IMGT_GENE-DB0142
MEROPS011,385
MoonProt0279
PeroxiBase0755
REBASE0397
TCDB06,682
mycoCLAP0354
PTM databases
CarbonylDB01,157
DEPOD0239
GlyConnect0495
PhosphoSitePlus039,004
SwissPalm07,256
UniCarbKB0584
iPTMnet051,228
Polymorphism and mutation databases
BioMuta017,240
DMDM016,296
dbSNP012,440
2D gel databases
COMPLUYEAST-2DPAGE097
DOSAC-COBS-2DPAGE0145
OGP0374
REPRODUCTION-2DPAGE01,038
SWISS-2DPAGE01,178
UCD-2DPAGE0497
World-2DPAGE0918
Proteomic databases
EPD020,231
MaxQB029,725
PRIDE0224,921
PaxDb0124,341
PeptideAtlas032,081
ProMEX0453
TopDownProteomics02,976
Protocols and materials databases
DNASU018,895
Genome annotation databases
Ensembl050,284
EnsemblBacteria0335,367
EnsemblFungi028,841
EnsemblMetazoa010,356
EnsemblPlants021,242
EnsemblProtists04,785
GeneDB0516
GeneID0280,018
Gramene021,242
KEGG0474,882
PATRIC091,769
UCSC045,520
VectorBase0495
WBParaSite034
Organism-specific databases
ArachnoServer01,140
Araport015,672
CGD01,970
CTD073,871
ConoServer0866
DisGeNET014,615
EchoBASE04,159
EcoGene04,293
EuPathDB037,658
FlyBase05,841
GeneCards020,138
GeneReviews01,152
H-InvDB04,769
HGNC020,145
HPA016,795
LegioList0763
Leproma0669
MGI016,834
MIM014,981
MaizeGDB0505
MalaCards04,435
OpenTargets018,165
Orphanet03,286
PharmGKB018,330
PomBase05,129
PseudoCAP01,323
RGD07,948
SGD06,734
TAIR014,507
TubercuList02,151
VGNC03,712
WormBase04,578
Xenbase04,537
ZFIN03,011
dictyBase04,097
euHCVdb044
neXtProt020,183
Phylogenomic databases
GeneTree059,090
HOGENOM0391,014
HOVERGEN075,934
InParanoid0136,833
KO0403,110
OMA0416,260
OrthoDB0293,037
PhylomeDB095,560
TreeFam045,258
eggNOG0331,220
Enzyme and pathway databases
BRENDA012,100
BioCyc0154,289
Reactome036,719
SABIO-RK03,854
SIGNOR04,063
SignaLink03,027
UniPathway0123,428
Other
ChiTaRS020,443
EvolutionaryTrace016,617
GeneWiki010,282
GenomeRNAi022,005
PMAP-CutDB01,462
PRO095,561
Gene expression databases
Bgee056,276
CleanEx029,387
CollecTF0133
ExpressionAtlas051,551
Genevisible055,222
Ontologies
Family and domain databases
CDD0166,030
Gene3D0291,684
HAMAP0326,925
InterPro0538,340
PANTHER0257,903
PIRSF0107,661
PRINTS0117,248
PROSITE0297,881
Pfam0514,137
ProDom028,949
SFLD06,500
SMART0141,532
SUPFAM0375,324
TIGRFAMs0272,581

Web resource

5,772 UniProtKB/Swiss-Prot entries have at least one link to a webpage of general interest on the protein.

Amino acid distribution statistics

    • Aliphatic
    • Acidic
    • Small hydroxy
    • Basic
    • Amide
    • Aromatic
    • Sulfur

    Miscellaneous Statistics

    16,274 entries are encoded on a mitochondrion, and 3,804 are encoded on a plasmid.

    12,188 entries are encoded on a plastid, of which 21 are encoded on apicoplasts, 11,623 on chloroplasts, 51 on organellar chromatophores, 145 on cyanelles, 149 on non-photosynthetic plastids and 17 on unspecified types of plastid.

    Cookie policy

    We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health