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Protein

Glutaredoxin-1

Gene

TO2L

Organism
Vaccinia virus (strain Tian Tan) (VACV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has thioltransferase and dehydroascorbate reductase activities.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Gene namesi
ORF Names:TO2L
OrganismiVaccinia virus (strain Tian Tan) (VACV)
Taxonomic identifieri10253 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000163220 Componenti: Genome

Subcellular locationi

  • Virion
  • Note: Localizes to the virion core.By similarity

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001416171 – 108Glutaredoxin-1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 26Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliQ77TL9
SMRiQ77TL9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 106GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q77TL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEFVQQRL ANNKVTIFVK YTCPFCRNAL DILNKFSFKR GAYEIVDIKE
60 70 80 90 100
FKPENELRDY FEQITGGRTV PRIFFGKTSI GGYSDLLEID NMDALGDILS

SIGVLRTC
Length:108
Mass (Da):12,355
Last modified:July 5, 2004 - v1
Checksum:i8C754AE57D7F54D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095689 Genomic DNA Translation: AAF33928.1

Similar proteinsi

Entry informationi

Entry nameiGLRX1_VACCT
AccessioniPrimary (citable) accession number: Q77TL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health