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3D-structure annotation in UniProtKB/Swiss-Prot

Manual annotation of entries with 3D-structures has high priority, for the following reasons:

  • 3D-structures shed light on protein architecture and provide proof for the existence of a given protein fold.
  • They show the assembly of multi-protein complexes, and the details of interactions between different proteins, such as an enzyme and its target.
  • 3D-structures yield detailed information about the interactions of a protein with its ligands (substrates, ions, cofactors or regulatory molecules), and so help to elucidate enzyme mechanisms and identify active site residues.
  • They help to attribute a function to so-far hypothetical proteins.
  • They show post-translational modifications.
  • 3D-structures pinpoint the exact position of a residue that causes a genetic disease when it is mutated.

UniProtKB/Swiss-Prot document: Index of PDB cross-references in UniProtKB/Swiss-Prot
Related keywords: 3D-structure
3D-structure databases

How can I retrieve all UniProtKB entries for which the 3D structure is known?
Why do I find many cross-references to PDB in UniProtKB/Swiss-Prot?

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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