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Protein

Cell surface-binding protein

Gene

D8L

Organism
Vaccinia virus (strain Copenhagen) (VACV)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface-binding protein
Alternative name(s):
Carbonic anhydrase homolog
Gene namesi
ORF Names:D8L
OrganismiVaccinia virus (strain Copenhagen) (VACV)
Taxonomic identifieri10249 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000008269 Componenti: Genome

Subcellular locationi

  • Virion membrane Curated
  • Note: Component of the mature virion (MV) membrane.Curated

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 275Virion surfaceSequence analysisAdd BLAST275
Transmembranei276 – 294HelicalSequence analysisAdd BLAST19
Topological domaini295 – 304IntravirionSequence analysis10

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774491 – 304Cell surface-binding proteinAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi262InterchainBy similarity

Post-translational modificationi

Apparently non-glycosylated.

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliP20508
SMRiP20508
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 235Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000IE

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P20508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQQLSPINI ETKKAISNAR LKPLDIHYNE SKPTTIQNTG KLVRINFKGG
60 70 80 90 100
YISGGFLPNE YVLSSLHIYW GKEDDYGSNH LIDVYKYSGE INLVHWNKKK
110 120 130 140 150
YSSYEEAKKH DDGLIIISIF LQVSDHKNVY FQKIVNQLDS IRSANTSAPF
160 170 180 190 200
DSVFYLDNLL PSTLDYFTYL GTTIKHSADA VWIIFPTPIN IHSDQLSKFR
210 220 230 240 250
TLLSSSNHDG KPYYITENYR NPYKLNDDTQ VYYSGEIIRA ATTSPARENY
260 270 280 290 300
FMRWLSDLRE TCFSYYQKYI EGNKTFAIIA IVFVFILTAI LFLMSRRYSR

EKQN
Length:304
Mass (Da):35,327
Last modified:February 1, 1991 - v1
Checksum:i3FFA31BE3091EEC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA Translation: AAA48107.1
PIRiG42515 CRVZ7P

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35027 Genomic DNA Translation: AAA48107.1
PIRiG42515 CRVZ7P

3D structure databases

ProteinModelPortaliP20508
SMRiP20508
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG090000IE

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAHH_VACCC
AccessioniPrimary (citable) accession number: P20508
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1991
Last sequence update: February 1, 1991
Last modified: June 20, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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