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Protein

Protein I2

Gene

I2L

Organism
Vaccinia virus (strain L-IVP) (VACV)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Late protein which probably plays a role in virus entry into the host cell.By similarity

GO - Biological processi

Keywordsi

Biological processViral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Protein I2
Gene namesi
ORF Names:I2L
OrganismiVaccinia virus (strain L-IVP) (VACV)
Taxonomic identifieri31531 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000995671 – 73Protein I2Add BLAST73

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 64Poly-Leu6

Sequence similaritiesi

Belongs to the chordopoxvirinae I2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR009175 Poxvirus_I2
PfamiView protein in Pfam
PF12575 Pox_EPC_I2-L1, 1 hit
PIRSFiPIRSF003766 VAC_I2L, 1 hit

Sequencei

Sequence statusi: Complete.

P68605-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKLYAAIFG VFMGSPEDDL TDFIEIVKSV LSDEKTVTST NNTGCWGWYW
60 70
LIIIFFIVLI LLLLIYLYLK VVW
Length:73
Mass (Da):8,499
Last modified:December 7, 2004 - v1
Checksum:i9AA89F7883384C72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61165 Genomic DNA Translation: CAA43474.1
PIRiB29889 WZVZI2
RefSeqiYP_232953.1, NC_006998.1

Genome annotation databases

GeneIDi3707604
KEGGivg:3707604

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61165 Genomic DNA Translation: CAA43474.1
PIRiB29889 WZVZI2
RefSeqiYP_232953.1, NC_006998.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707604
KEGGivg:3707604

Family and domain databases

InterProiView protein in InterPro
IPR009175 Poxvirus_I2
PfamiView protein in Pfam
PF12575 Pox_EPC_I2-L1, 1 hit
PIRSFiPIRSF003766 VAC_I2L, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI2_VACCP
AccessioniPrimary (citable) accession number: P68605
Secondary accession number(s): P12922
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 7, 2004
Last modified: September 16, 2015
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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