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Protein

Cell surface-binding protein

Gene

RPXV102

Organism
Rabbitpox virus (strain Utrecht) (RPV)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface-binding protein
Alternative name(s):
Carbonic anhydrase homolog
Gene namesi
Ordered Locus Names:RPXV102
OrganismiRabbitpox virus (strain Utrecht) (RPV)
Taxonomic identifieri45417 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiOryctolagus cuniculus (Rabbit) [TaxID: 9986]

Subcellular locationi

  • Virion membrane Curated
  • Note: Component of the mature virion (MV) membrane.Curated

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 275Virion surfaceSequence analysisAdd BLAST275
Transmembranei276 – 294HelicalSequence analysisAdd BLAST19
Topological domaini295 – 304IntravirionSequence analysis10

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774471 – 304Cell surface-binding proteinAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi262InterchainBy similarity

Post-translational modificationi

Apparently non-glycosylated.By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.

Structurei

3D structure databases

ProteinModelPortaliQ6RZI9
SMRiQ6RZI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 235Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6RZI9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPQQLSPINI ETKKAISNAR LKPLDIHYNE SKPTTIQNTG KLVRINFKGG
60 70 80 90 100
YISGGFLPNE YVLSSLHIYW GKEDDYGSNH LIDVYKYSGE INLVHWNKKK
110 120 130 140 150
YSSYEEAKKH DDGLIIISIF LQVSDHKNVY FQKIVNQLDS IRSANTSAPF
160 170 180 190 200
DSVFYLDNLL PSTLDYFTYL GTTINHSADA AWIIFPTPIN IHSDQLSKFR
210 220 230 240 250
TLLSSSNHDG KPHYITENYR NPYKLNDDTQ VYYSGEIIRA ATTSPARDNY
260 270 280 290 300
FMRWLSDLRE TCFSYYQKYI EGNKTFAIIA IVFVFILTAI LFLMSRRYSR

EKQN
Length:304
Mass (Da):35,245
Last modified:July 5, 2004 - v1
Checksum:i64E6B0A05096FFC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484669 Genomic DNA Translation: AAS49815.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY484669 Genomic DNA Translation: AAS49815.1

3D structure databases

ProteinModelPortaliQ6RZI9
SMRiQ6RZI9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAHH_RABPU
AccessioniPrimary (citable) accession number: Q6RZI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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